激情婷婷丁香色五月综合深爱野花,婷婷伊人五月天色综合激情网,四房播播丁香开心婷婷伊人,狠狠色丁香婷婷综合,伊人色综合久久天天五月婷,色婷婷综合五月天,狠狠色丁香婷婷综合基地,天天草综合,狠狠干天天色,天天干天天操综合,色五月天天,天天插天天色,天天摸天天草,天天插天天爱,WWW天天干天天色

Klotho is a type-I transmembrane protein that is associated with many functions. A novel ?-glucuronidase, Klotho has been associated with phosphate regulation, organ protection, and aging, among others. Though a single gene, it has three major isoforms: the transmembrane form, a shed soluble form, and a truncated soluble form. The extracellular portion of the protein consists of two glycosyl hydrolase domains referred to as KL1 and KL2. Upon cleavage at the base of the extracellular domain the protein becomes the shed soluble form and is an active form that functions as a hormone. Importantly, Klotho is a receptor and a co-receptor of the phosphate regulation protein FGF-23. While Klotho/FGF-23 homeostasis has primarily been focused on phosphate and vitamin D regulation, continuing research is associating Klotho and FGF-23 with functionality that impacts the heart, bones, blood vessels, and parathyroid gland.

The MicroVue Klotho ***** is a sandwich enzyme immuno***** in a microtiter plate format utilizing a capture monoclonal anti-Klotho antibody specific to the KL2 region coated on the plate and a detection mouse monoclonal anti-Klotho antibody specific to the KL1 region.